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August 20, 2013

European Study Confirms Anti-Malarial Effect of Green Tea Extract

A research study published by a number of scientists in Italy demonstrates that green tea extracts do have a positive impact in treating malaria, in vitro.  While this study predates the recent Plandaí­ Biotechnology, Inc. (OTCQB – PLPL - $0.58 – Spec Buy) malaria study, it nonetheless supports the Company’s series of tests to date that green tea extracts demonstrate an antimalarial effect.

In the Italy-based study, the scientists found that “…a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin (a key malaria treatment)without interfering with the folate pathway.”  Moreover, the tests showed that the combination of artemisinin and the green tea catechins displayed a strong combined effect.

Interestingly, while in previous studies Plandaí­ confirmed the same effect, in its most recent tests, the Company recently announced incredible results from its second round of in vitro testing of Phytofare™ Catechin Complex, used to kill the malaria parasite plasmodium falciparum.  The results of this independent investigation confirmed a twelve-times greater efficacy in killing the parasite. It should be noted that in this round the Company elected to use the complete Phytofare™ complex and not just the isolated EGCG (Epigallocatechin Gallate) catechin used in earlier studies.

Since malaria is not a disease that affects people in most Western nations, many people are unaware of the reach of this deadly disease which potentially impacts hundreds of millions of people and kills 600,000 in the African continent alone.  As a result, success in developing a highly effective commercial botanical extract to treat malaria is a very lucrative and therapeutic opportunity for Plandaí­. 

To that end, management plans to complete a commercial delivery system by encapsulating Phytofare™ Catechin Complex into a proprietary nano-delivery system that is expected to deliver improved absorption and protection against gut metabolization, allowing the Phytofare™ to remain protected and intact until it reaches the bloodstream. In addition, further independent scientific investigations of Phytofare™ Catechin Complex, combined with arteseminin which has also been processed into a Phytofare™ extract, will be undertaken both in vitro and in mouse models to validate the extract for oral consumption as an antimalarial drug target. Pending favorable results, the company will seek approval to commence a Phase II human clinical trial.

For more information, refer to our previous PLPL Reports, Updates and Hot Topics by visiting www.GoldmanResearch.com

Senior Analyst: Robert Goldman
Rob Goldman has over 20 years of investment and company research experience as a senior research analyst and as a portfolio and mutual fund manager. During his tenure as a sell side analyst, Rob was a senior member of Piper Jaffray's Technology and Communications teams. Prior to joining Piper, Rob led Josephthal & Co.'s Washington-based Emerging Growth Research Group. In addition to his sell-side experience Rob served as Chief Investment Officer of a boutique investment management firm and Blue and White Investment Management, where he managed Small Cap Growth portfolios and The Blue and White Fund.

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I, Robert Goldman, hereby certify that the view expressed in this research report accurately reflect my personal views about the subject securities and issuers. I also certify that no part of my compensation was, is, or will be, directly or indirectly, related to the recommendations or views expressed in this research report.

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