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July 22, 2013

Nuvilex Delivery Platform May Emerge As The Holy Grail To Cancer Treatment

A number of biotech and pharmaceutical firms have switched gears in their effort to successfully fight cancer. In addition to developing drugs that directly or indirectly fight cancer cells, or could be potentially used as a preventive measure, many firms are focusing their attention on devising more effective drug delivery methods.  Perhaps these firms are following in the footsteps of Nuvilex, Inc. (OTCQB – NVLX - $0.15 – Spec Buy). Nuvilex is an international firm engaged in using its live-cell encapsulation technology to develop treatments for pancreatic and other cancers along with the examining the use of constituents of medical marijuana to develop treatments for oncology patients.

Earlier this year, nanomedicine-based firms executed successful clinical trials and engaged in large development deals with some of the world’s leading drug giants.  These firms have demonstrated an ability to encapsulate potent drugs in tiny particles measuring billionths of a meter in diameter; this technology is opening up new options for super-accurate drug delivery, increasing precision hits at the site of disease with limited side effects.  This is a similar concept to Nuvilex’s approach where cells containing high levels of enzymes that activate pro-drugs to their cancer-killing forms are encapsulated and placed in proximity to the tumor and therefore, the cancer drugs are targeted directly at the tumor with greater efficacy than traditional methods and with far less drug-related toxicity.

In July of this year, researchers at Purdue University announced that they have developed a concept to potentially improve delivery of drugs for cancer treatment using nanoparticles that concentrate and expand in the presence of higher acidity found in tumor cells.

The concept involves using nanoparticles made of "weak polybases," compounds that expand when transported into environments mimicking tumor cells, which have a higher acidity than surrounding tissues. The researchers used sophisticated modeling to show how the particles would accumulate in regions of higher acidity and remain there long enough to deliver anticancer drugs. 

Whether one is referring to high-profile nanomedicine-based firms or pre-clinical university research, the fact that drug delivery is at the forefront of the fight against cancer bodes well for Nuvilex, which has already demonstrated significant efficacy and low toxicity in its Phase II inoperable pancreatic cancer trials. Moreover, it should capture the attention of new investors and prospective partners as well.

Senior Analyst: Robert Goldman
Rob Goldman has over 20 years of investment and company research experience as a senior research analyst and as a portfolio and mutual fund manager. During his tenure as a sell side analyst, Rob was a senior member of Piper Jaffray's Technology and Communications teams. Prior to joining Piper, Rob led Josephthal & Co.'s Washington-based Emerging Growth Research Group. In addition to his sell-side experience Rob served as Chief Investment Officer of a boutique investment management firm and Blue and White Investment Management, where he managed Small Cap Growth portfolios and The Blue and White Fund.

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I, Robert Goldman, hereby certify that the view expressed in this research report accurately reflect my personal views about the subject securities and issuers. I also certify that no part of my compensation was, is, or will be, directly or indirectly, related to the recommendations or views expressed in this research report.

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