June 5, 2013
Low Level of Toxicity a Major Plus for Nuvilex
As Nuvilex Inc. (QTCQB - NVLX - $0.14 - Spec Buy) management can attest, scientists and clinicians often approach drug development and treatment very differently.
When academicians and scientists engage in research and studies to treat deadly or highly infectious diseases, the degree of efficacy and mechanism of action are two key elements in which they focus attention. After all, to a great degree, the long term success or the potential outcome of the ongoing research and tests are largely based upon these factors.
On the other hand, clinicians, who are the first line of defense via personal relationships with their patients, weigh quality of life and toxicity as well as efficacy when prescribing treatment for deadly diseases. This fact is best exemplified with the clinician's approach to cancer treatment. In fact it could be one of the key reasons why if ultimately approved the use of Nuvilex's pancreatic cancer treatment approach may emerge as one of the disease's treatments of choice.
The results of its Phase II trial of 14 patients demonstrated that the patients' median survival rate doubled compared to historical control and results of the current gold standard used today, which is Gemzar®. Plus, the 1-year survival rate was triple that of control and double that of the standard Gemzar® therapy. Perhaps the most telling component of the trial was the fact that only one-third of the standard chemotherapy dosage was used, thereby measurably increasing the patient quality of life.
For example, according to the Gemzar.com website, the side effects of using the treatment for pancreatic cancer are many, with varying ranges of severity. On the mild side, nausea, diarrhea, fever and hair loss are common in anywhere from 3:10 to 7:10 of patients. In addition, 7 out of 10 patients suffered from anemia, low white blood cell count, and changes in their liver function tests.
In future tests, Nuvilex will likely use stand-alone Gemzar® therapy as a comparator. But, if early results are an indication, it is not just efficacy that could serve patients well, but if combined with an approved low toxicity due to the reduced chemotherapy dosage, clinicians and patients could seek out the treatment in droves.
Senior Analyst: Robert Goldman
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